Yohimbine-13C, d3

Yohimbine-13C, d3 is the 13C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.

Product Specifications

CAS Number

[1261254-59-4]

UNSPSC

12352005

Hazard Statement

H301+H311+H331

Target

Adrenergic Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease; Endocrinology

Purity

99.0

Solubility

10 mM in DMSO|DMSO : 5mg/mL (ultrasonic) |H2O : 1mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

[2H][13C]([2H])([2H])OC([C@@H]1[C@@]2([H])C[C@@]3([H])C4=C(CCN3C[C@]2([H])CC[C@@H]1O)C5=CC=CC=C5N4)=O

Molecular Formula

C20 13CH23D3N2O3

Molecular Weight

358.45

Precautions

H301+H311+H331

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Saeed SA, et al. Signaling mechanisms mediated by G-protein coupled receptors in human platelets. Acta Pharmacol Sin. 2004 Jul;25 (7) :887-892.|[3]Blanchard RJ, et al. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice. Pharmacol Biochem Behav. 1993 Mar;44 (3) :673-681.|[4]Fuller BB, et al. Downregulation of tyrosinase activity in human melanocyte cell cultures by yohimbine. J Invest Dermatol. 2000 Feb;114 (2) :268-276.