Spicamycin
Product Specifications
UNSPSC Description
Spicamycin, an adenine nucleoside antibiotic with antifungal and antitumor activities. Spicamycin is also a potent inducer of differentiation of myeloid leukemia cells. Spicamycin induces apoptosis in NB4 cells via down-regulation of Bcl-2 expression and modulation of PML protein[1][2].
Target Antigen
Antibiotic; Apoptosis; Bcl-2 Family; Fungal
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/spicamycin.html
Solubility
10 mM in DMSO
Smiles
OC[C@H](O)[C@]([C@H](NC(CNC(CCCCCCCCCCCCC(C)C)=O)=O)[C@@H](O)[C@H]1O)([H])O[C@@H]1NC2=C3C(N=CN3)=NC=N2
Molecular Weight
621.77
References & Citations
[1]Zhang WJ, et al. Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein. Jpn J Cancer Res. 2000 Jun;91(6):604-11. |[2]Hayakawa Y, et al. Spicamycin, a new differentiation inducer of mouse myeloid leukemia cells (Ml) and human promyelocytic leukemia cells (HL-60)[J]. Agricultural and biological chemistry, 1985, 49(9): 2685-2691.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-127130/Spicamycin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-127130/
Clinical Information
No Development Reported
CAS Number
87099-85-2
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