Pteropterin (monohydrate)

Pteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity[1][2].

Product Specifications

CAS Number

[6164-84-7]

Product Name Alternative

Pteroyltriglutamic (monohydrate)

UNSPSC

12352005

Target

Drug Metabolite; Folate Receptor (FR)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pteropterin-monohydrate.html

Solubility

10 mM in DMSO

Smiles

O=C(CC[C@H](NC(CC[C@H](NC(CC[C@H](NC(C1=CC=C(C=C1)NCC2=CN=C3NC(N)=NC(C3=N2)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)O.O

Molecular Formula

C29H35N9O13

Molecular Weight

717.64

References & Citations

[1]Stine ZE, et al. Targeting cancer metabolism in the era of precision oncology. Nat Rev Drug Discov. 2022 Feb;21 (2) :141-162. |[2]Muthu M, et al. Current Status and Future Prospects of Clinically Exploiting Cancer-specific Metabolism-Why Is Tumor Metabolism Not More Extensively Translated into Clinical Targets and Biomarkers? Int J Mol Sci. 2019 Mar 19;20 (6) :1385.