Aminooxy-PEG2-alcohol

Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Product Specifications

CAS Number

[185022-12-2]

UNSPSC

12352203

Hazard Statement

H302-H315-H318-H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aminooxy-peg2-alcohol.html

Solubility

10 mM in DMSO

Smiles

NOCCOCCO

Molecular Formula

C4H11NO3

Molecular Weight

121.14

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Marek Kwiatkowski. Conjugates of biologically active molecules to functionalized polymers. WO2013186632A2.|[2]Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb) . 2010 Dec 7;46 (45) :8651-3.