4-Hydroxy Atorvastatin lactone

4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589) . Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1].

Product Specifications

CAS Number

[163217-70-7]

Product Name Alternative

P-Hydroxyatorvastatin lactone; 4-ATL

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-hydroxy-atorvastatin-lactone.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C(C)C)N(CC[C@@H]2C[C@@H](O)CC(O2)=O)C(C3=CC=C(F)C=C3)=C1C4=CC=CC=C4)NC5=CC=C(O)C=C5

Molecular Formula

C33H33FN2O5

Molecular Weight

556.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Jemal M, et al. Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 1999;13 (11) :1003-15.