3-Morpholinosydnonimine

Product Specifications

CAS Number

[33876-97-0]

Product Name Alternative

SIN-1; Linsidomine

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis;Cytoskeleton;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/3-morpholinosydnonimine.html

Solubility

10 mM in DMSO

Smiles

[NH-]C1=C[N+](N2CCOCC2)=NO1

Molecular Weight

170.17

References & Citations

[1]He Y, et al. 3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. Biomed Pharmacother. 2018 Oct;106:1696-1704. |[2]An JM, et al. Neuroprotective effect of 3-morpholinosydnonimine against Zn²⁺-induced PC12 cell death. Eur J Pharmacol. 2015 Feb 5;748:37-44.|[3]Mattart L, et al. The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells. Cell Signal. 2012 Jan;24(1):199-213.|[4]Won KJ, et al. 3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration. Proteomics. 2011 Jan;11(2):193-201.