3-Morpholinosydnonimine
Product Specifications
CAS Number
33876-97-0
Product Name Alternative
SIN-1; Linsidomine
Type
Biochemical Assay Reagents
Related Pathways
Apoptosis;Cytoskeleton;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/3-morpholinosydnonimine.html
Solubility
10 mM in DMSO
Smiles
[NH-]C1=C[N+](N2CCOCC2)=NO1
Molecular Weight
170.17
References & Citations
[1]He Y, et al. 3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. Biomed Pharmacother. 2018 Oct;106:1696-1704. |[2]An JM, et al. Neuroprotective effect of 3-morpholinosydnonimine against Zn²⁺-induced PC12 cell death. Eur J Pharmacol. 2015 Feb 5;748:37-44.|[3]Mattart L, et al. The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells. Cell Signal. 2012 Jan;24(1):199-213.|[4]Won KJ, et al. 3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration. Proteomics. 2011 Jan;11(2):193-201.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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