Myristoyl coenzyme A (lithium)

Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA) . Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT) . And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Product Specifications

CAS Number

[187100-75-0]

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/myristoyl-coenzyme-a-lithium.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

O=C(SCCNC(CCNC([C@H](O)C(C)(C)COP(OP(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@]([H])(N2C=NC3=C(N)N=CN=C32)O1)(O)=O)(O)=O)=O)=O)CCCCCCCCCCCCC.[Li].[x]

Molecular Formula

C35H62N7O17P3S.xLi

References & Citations

[1]Raju RV, et al. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Mol Cell Biochem. 1996 May 24;158 (2) :107-13.