Myristoyl coenzyme A

Myristoyl coenzyme A is a myristoylated coenzyme A (CoA) . Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT) . And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

Product Specifications

CAS Number

[3130-72-1]

Product Name Alternative

14:0 Coenzyme A; S-Tetradecanoate-CoA; S-Tetradecanoate-coenzyme A

UNSPSC

12352204

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/myristoyl-coenzyme-a.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCCCCCCCCCCC)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32

Molecular Formula

C35H62N7O17P3S

Molecular Weight

977.89

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Raju RV, et al. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Mol Cell Biochem. 1996 May 24;158 (2) :107-13.