Territrem B
Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus[1][2].
Product Specifications
CAS Number
70407-20-4
UNSPSC
12352005
Hazard Statement
H301+H311, H330
Target
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/territrem-b.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
O[C@@]12[C@@]3([C@@](CC[C@]1(OC4=C(C(OC(C5=CC(OC)=C(C(OC)=C5)OC)=C4)=O)C2)C)(C(C)(C=CC3=O)C)O)C
Molecular Formula
C29H34O9
Molecular Weight
526.57
Precautions
H301+H311, H330
References & Citations
[1]Chen JW, et al. Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J Biol Chem. 1999 Dec 3;274 (49) :34916-23. |[2]Cheung J, et al. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. J Mol Neurosci. 2014 Jul;53 (3) :506-10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Frequently Asked Questions
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