Territrem B

Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus[1][2].

Product Specifications

CAS Number

[70407-20-4]

UNSPSC

12352005

Hazard Statement

H301+H311, H330

Target

Cholinesterase (ChE)

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/territrem-b.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O[C@@]12[C@@]3([C@@](CC[C@]1(OC4=C(C(OC(C5=CC(OC)=C(C(OC)=C5)OC)=C4)=O)C2)C)(C(C)(C=CC3=O)C)O)C

Molecular Formula

C29H34O9

Molecular Weight

526.57

Precautions

H301+H311, H330

References & Citations

[1]Chen JW, et al. Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J Biol Chem. 1999 Dec 3;274 (49) :34916-23. |[2]Cheung J, et al. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. J Mol Neurosci. 2014 Jul;53 (3) :506-10.