Mal-Phe-C4-VC-PAB-DMEA-PNU-159682
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-Phe-C4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682[1].
Product Specifications
CAS Number
2259318-54-0
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-phe-c4-vc-pab-dmea-pnu-159682.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(COC(N(C)CCN(C)C(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC7=CC=C(N8C(C=CC8=O)=O)C=C7)=O)=O)=O)C=C6)=O)=O)=O)(O)C4)C(O)=C9C(C(C%10=C(OC)C=CC=C%10C9=O)=O)=C5O
Molecular Formula
C70H83N9O22
Molecular Weight
1402.46
References & Citations
[1]John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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