Apoptolidin

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].

Product Specifications

CAS Number

[194874-06-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; ATP Synthase

Type

Natural Products

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apoptolidin.html

Purity

95.60

Solubility

DMSO : 1 mg/mL (ultrasonic; warming)

Smiles

O[C@H]([C@](OC(/C(C)=C/C(C)=C/C(C)=C/[C@H]1C)=O)([H])C[C@@H]([C@H](CC/C=C(/C=C/[C@H]1O[C@H](O[C@H]2C)[C@H]([C@@H]([C@H]2OC)O)O)C)O)OC)[C@](O[C@@H]([C@@H]3C)C[C@H](COC)O[C@H](O[C@H]4C)C[C@](O)([C@H]4O[C@H](O[C@@H]5C)C[C@H]([C@@H]5O)OC)C)([C@@H]([C@H]3O)C)O

Molecular Formula

C58H96O21

Molecular Weight

1129.37

Precautions

H302, H315, H319, H335

References & Citations

[1]J W Kim, et al. Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. J Antibiot (Tokyo) . 1997 Jul;50 (7) :628-30.|[2]A R Salomon, et al. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F (0) F (1) -ATPase. Proc Natl Acad Sci U S A. 2000 Dec 19;97 (26) :14766-71.