AS2521780
AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM.
Product Specifications
CAS Number
1214726-89-2
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/AS2521780.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CN=C(NCC2=CC=CN=C2SC)N=C1NC[C@]34C[C@]5([H])[C@@H](NC[C@H]6CC[C@H](O)CC6)[C@@](C4)([H])CC(C5)C3
Molecular Formula
C30H41N7OS
Molecular Weight
547.76
References & Citations
[1]Fukahori H, et al. Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity. Eur J Pharmacol. 2014 Dec 15;745:217-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCδ; PKCε; PKCθ
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