Malonganenone A
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x[1].
Product Specifications
CAS Number
882403-69-2
UNSPSC
12352005
Target
HSP; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/malonganenone-a.html
Solubility
10 mM in DMSO
Smiles
O=C1N=CN(C)C2=C1N(C/C=C(C)/CC/C=C(C)/CCC/C(C)=C\C(CC(C)C)=O)C=N2
Molecular Formula
C26H38N4O2
Molecular Weight
438.61
References & Citations
[1]Ingrid L Cockburn, et al. Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity. Biol Chem. 2014 Nov 1;395 (11) :1353-62.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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