Nemadipine-A

Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2].

Product Specifications

CAS Number

[54280-71-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nemadipine-a.html

Purity

98.0

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

CC1=C(C(C(C(OCC)=O)=C(N1)C)C2=C(C(F)=C(C(F)=C2F)F)F)C(OCC)=O

Molecular Formula

C19H18F5NO4

Molecular Weight

419.34

Precautions

H315, H319, H335

References & Citations

[1]Peter I Joyce, et al. The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular. PLoS Genet. 2012;8 (3) :e1002602.degeneration|[2]Seong Ho Park, et al. Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis. Biomol Ther (Seoul) . 2013 Jan;21 (1) :29-34.