Abemaciclib metabolite M18
Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].
Product Specifications
CAS Number
2704316-81-2
Product Name Alternative
LSN3106729
UNSPSC
12352005
Target
CDK; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abemaciclib-metabolite-m18.html
Purity
98.01
Solubility
DMSO : 7.69 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C=N1)=C(C2=CC(N(C(C)C)C(CO)=N3)=C3C(F)=C2)N=C1NC4=NC=C(C=C4)CN5CCNCC5
Molecular Formula
C25H28F2N8O
Molecular Weight
494.54
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Citation 01
Indonesian Journal of Pharmaceutics. 2025.|J Pharm Biomed Anal. 2021 Sep 5:203:114225.
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