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Sordarin (sodium)

Sordarin sodium is an eEF2 inhibitor and antibiotic. Sordarin sodium's function is dependent on the diphthamide modification on eEF2. Sordarin sodium inhibits protein synthesis by preventing the binding of eEF2 to the ribosome complex. Sordarin sodium has antifungal activity[1][2].

Product Specifications

CAS Number

463356-00-5

UNSPSC

12352005

Target

Antibiotic; CaMK; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sordarin-sodium.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(O[Na])[C@](C(C(C)C)=C[C@H]1C2)([C@]1(CO[C@@H]([C@@H](O)[C@H](O)[C@@H]3OC)O[C@@H]3C)C[C@]4([C@]5(CC[C@H]4C)[H])[H])[C@]25C=O

Molecular Formula

C27H39NaO8

Molecular Weight

514.58

References & Citations

[1]Wael Abdel-Fattah, et al. Insights into diphthamide, key diphtheria toxin effector. Toxins (Basel) . 2013 May 3;5 (5) :958-68.|[2]Biprashekhar Chakraborty, et al. Structure-based designing of sordarin derivative as potential fungicide with pan-fungal activity. J Mol Graph Model. 2016 May;66:133-42.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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