RORγt agonist 1
RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist with an EC50 of 20.8 nM. RORγt agonist 1 showes high metabolic stability, improved aqueous solubility and excellent mouse PK profile. RORγt agonist 1 is a potential candidate of RORγt agonist for cancer immunotherapy[1].
Product Specifications
CAS Number
2377378-89-5
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ror-gamma-t-agonist-1.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(OC(F)F)=CC(C2=CC=C(CC(CC(O)=O)N3S(C4=CC(C(F)(F)F)=CC=C4)(=O)=O)C3=C2)=C1
Molecular Formula
C24H17F6NO5S
Molecular Weight
545.45
References & Citations
[1]Zhu Y, et al. Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists. Eur J Med Chem. 2019 Aug 6;182:111589.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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