GS-443902
Product Specifications
UNSPSC Description
GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir[1][2].
Target Antigen
DNA/RNA Synthesis; Drug Metabolite; HCV; RSV; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-443902.html
Purity
99.87
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=P(OP(O)(O)=O)(O)OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O)=O
Molecular Weight
531.20
References & Citations
[1]Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661.|[2]Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7.|[3]Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5.Acta Pharm Sin B. 2021 Mar 22.|Cell. 2022 Nov 10;185(23):4347-4360.e17.|Chem Biol Interact. 2021 Apr 19;109480.|Current Research in Pharmacology and Drug Discovery. 2021, 100045.|Int J Mol Sci. 2022, 23(15), 8302.|Research Square Preprint. 2022 May.|bioRxiv. 2021 Jul 21:2021.07.21.453274. |J Med Chem. 2024 May 1.|Nat Commun. 2021 Oct 4;12(1):5811.|Sci Rep. 2022 Nov 2;12(1):18506.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126303/GS-443902-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126303/GS-443902-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1355149-45-9
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