GS-443902
GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir[1][2].
Product Specifications
CAS Number
1355149-45-9
Product Name Alternative
GS-441524 triphosphate; Remdesivir metabolite
UNSPSC
12352005
Target
DNA/RNA Synthesis; Drug Metabolite; HCV; RSV; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-443902.html
Purity
99.87
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=P(OP(O)(O)=O)(O)OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O)=O
Molecular Formula
C12H16N5O13P3
Molecular Weight
531.20
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
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