SGC6870
SGC6870, a chemical probe, is a potent, selective and cytoactive allosteric inhibitor of PRMT6 with IC50 of 77 nM[1].
Product Specifications
CAS Number
2561471-27-8
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sgc6870.html
Purity
99.80
Solubility
10 mM in DMSO
Smiles
O=C1CN(C(C2=CC=C(Br)S2)=O)[C@H](C3=CC(C)=CC(C)=C3)C4=CC(C)=CC=C4N1
Molecular Formula
C23H21BrN2O2S
Molecular Weight
469.39
References & Citations
[1]Shen Y, et al. A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J Med Chem. 2021 Apr 8;64 (7) :3697-3706. doi: 10.1021/acs.jmedchem.0c02160. Epub 2021 Feb 16. PMID: 33591753; PMCID: PMC8035306.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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