SGC6870

SGC6870, a chemical probe, is a potent, selective and cytoactive allosteric inhibitor of PRMT6 with IC50 of 77 nM[1].

Product Specifications

CAS Number

[2561471-27-8]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sgc6870.html

Purity

99.80

Solubility

10 mM in DMSO

Smiles

O=C1CN(C(C2=CC=C(Br)S2)=O)[C@H](C3=CC(C)=CC(C)=C3)C4=CC(C)=CC=C4N1

Molecular Formula

C23H21BrN2O2S

Molecular Weight

469.39

References & Citations

[1]Shen Y, et al. A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J Med Chem. 2021 Apr 8;64 (7) :3697-3706. doi: 10.1021/acs.jmedchem.0c02160. Epub 2021 Feb 16. PMID: 33591753; PMCID: PMC8035306.