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CDK4/6-IN-3

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of i of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1].

Product Specifications

CAS Number

2366237-37-6

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk4-6-in-3.html

Solubility

10 mM in DMSO

Smiles

FC1=CN=C(NC2=NC=C(N3CC4(CN(CC)C4)C3)C=C2)N=C1C5=C([C@H](C)CCCC6)N6N=C5

Molecular Formula

C25H31FN8

Molecular Weight

462.57

References & Citations

[1]Bronner SM, et al. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett. 2019 Aug 15;29 (16) :2294-2301.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK1; CDK4; CDK6

Frequently Asked Questions

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