NOC-5
NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors. NOC-5 is able to increase intracellular XIAP and Aven levels, potentially leading to the inhibition of caspase-9 activity following increased mitochondrial permeability[1][2].
Product Specifications
CAS Number
146724-82-5
UNSPSC
12352211
Hazard Statement
H242
Target
IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/noc-5.html
Purity
98.50
Solubility
10 mM in DMSO
Smiles
CC(N(CCCN)N(N=O)O)C
Molecular Formula
C6H16N4O2
Molecular Weight
176.22
Precautions
H242
References & Citations
[1]Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24.|[2]Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38 (7) :799-802.|[3]Starikova EG, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38 (7) :799-802.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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