NOC-5

NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors. NOC-5 is able to increase intracellular XIAP and Aven levels, potentially leading to the inhibition of caspase-9 activity following increased mitochondrial permeability[1][2].

Product Specifications

CAS Number

[146724-82-5]

UNSPSC

12352211

Hazard Statement

H242

Target

IAP

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/noc-5.html

Purity

98.50

Solubility

10 mM in DMSO

Smiles

CC(N(CCCN)N(N=O)O)C

Molecular Formula

C6H16N4O2

Molecular Weight

176.22

Precautions

H242

References & Citations

[1]Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24.|[2]Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38 (7) :799-802.|[3]Starikova EG, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38 (7) :799-802.