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S1PR1 modulator 1

S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC50 of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4[1].

Product Specifications

CAS Number

[2328109-05-1]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s1pr1-modulator-1.html

Purity

99.52

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming)

Smiles

CC1=CC=CC=C1N2C(/C(S/C2=N\CCC)=C/C3=CC=C(OC(C)=O)C(C)=C3)=O

Molecular Formula

C23H24N2O3S

Molecular Weight

408.51

References & Citations

[1]Bell M, et al. Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1) . ACS Med Chem Lett. 2019 Feb 14;10 (3) :341-347.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-126145/S1PR1-modulator-1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-126145/S1PR1-modulator-1-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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