Top1 inhibitor 1
Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].
Product Specifications
CAS Number
[2302772-05-8]
UNSPSC
12352203
Target
ADC Payload; Topoisomerase
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/top1-inhibitor-1.html
Purity
99.67
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC(C=C1)=CC=C1C2=CC=C(N=CC(C3=NN=CO3)=C4NCCCN5C=NC=C5)C4=C2
Molecular Formula
C24H22N6O2
Molecular Weight
426.47
References & Citations
[1]Kundu B, et al. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. J Med Chem. 2019 Apr 11; 62 (7) :3428-3446.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
Curated Selection
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