WS-383 (free base)
WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].
Product Specifications
CAS Number
[2247543-65-1]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ws-383-free-base.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23
Molecular Formula
C18H20ClN9S2
Molecular Weight
461.99
References & Citations
[1]Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.J Med Chem. 2019 Mar 14;62 (5) :2772-2797.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6147625-01 0.1 mL
HORMAD1 (HORMA Domain-containing Protein 1, Cancer/Testis Antigen 46, CT46, Newborn Ovary HORMA Protein, NOHMA, DKFZp434A1315, NOHMA, RP11-363I22.1) (FITC)
Ask
View Details MBS6147625-02 5x 0.1 mL
HORMAD1 (HORMA Domain-containing Protein 1, Cancer/Testis Antigen 46, CT46, Newborn Ovary HORMA Protein, NOHMA, DKFZp434A1315, NOHMA, RP11-363I22.1) (FITC)
Ask
View Details 
MBS6374923-01 0.1 mL
CSNK2A2 (Casein Kinase II Subunit alpha', CK II alpha', CK2A2) (MaxLight 405)
Ask
View Details