WS-383 (free base)
Product Specifications
UNSPSC Description
WS-383 free base is a potent, selective and reversible inhibitor of?DCN1-UBC12?interaction, with an?IC50?of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].
Target Antigen
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ws-383-free-base.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23
Molecular Weight
461.99
References & Citations
[1]Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.J Med Chem. 2019 Mar 14;62(5):2772-2797.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126075/WS-383-free-base-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126075/
Clinical Information
No Development Reported
CAS Number
2247543-65-1
Curated Selection
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