SAR107375

SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively[1].

Product Specifications

CAS Number

1184300-63-7

UNSPSC

12352005

Target

Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sar107375.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(Cl)S1)NC[C@H](NS(=O)(C2=CC=CC(N3C(CCC3)=O)=C2C)=O)C(N4CCN(C)CC4)=O

Molecular Formula

C24H30ClN5O5S2

Molecular Weight

568.11

References & Citations

[1]Jerome Meneyrol, et al. 5-Chlorothiophene-2-carboxylic acid [ (S) -2-[2-methyl-3- (2-oxopyrrolidin-1-yl) benzenesulfonylamino]-3- (4-methylpiperazin-1-yl) -3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor. J Med Chem. 2013 Dec 12;56 (23) :9441-56.