(R) - (+) -Anatabine

(R) - (+) -Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent α4β2 nAChR agonist[1]. Anatabine inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP) . Anatabine has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment[2][3][4].

Product Specifications

CAS Number

[126454-22-6]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Amyloid-β; nAChR; NF-κB

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-plus-anatabine.html

Solubility

10 mM in DMSO

Smiles

[C@H]1(C2=CC=CN=C2)CC=CCN1

Molecular Formula

C10H12N2

Molecular Weight

160.22

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Jothi L. Nallasivam, et al. Synthetic modifications of bifunctional homoallylamines: Synthesis of 2-arylpiperidines, (R) -anatabine and (R) -anabasine. An International Journal for Rapid Communication of Synthetic Organic Chemistry. Volume 49, 2019-Issue 21: 2815-2822.|[2]Paris D, et al. Anatabine lowers Alzheimer's Aβ production in vitro and in vivo. Eur J Pharmacol. 2011 Nov 30;670 (2-3) :384-91.|[3]Xing H, et al. A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine. Mar Drugs. 2020 Feb 11;18 (2) . pii: E106.|[4]eo EJ, et al. Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease. Pharmacol Res. 2018 Mar;129:262-273.