(R) - (+) -Anatabine
(R) - (+) -Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent α4β2 nAChR agonist[1]. Anatabine inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP) . Anatabine has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment[2][3][4].
Product Specifications
CAS Number
126454-22-6
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Amyloid-β; nAChR; NF-κB
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-plus-anatabine.html
Solubility
10 mM in DMSO
Smiles
[C@H]1(C2=CC=CN=C2)CC=CCN1
Molecular Formula
C10H12N2
Molecular Weight
160.22
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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