T-2513 (hydrochloride)
T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].
Product Specifications
CAS Number
187793-52-8
UNSPSC
12352005
Target
DNA/RNA Synthesis; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t-2513-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=C(OCCCN)C=C51.Cl
Molecular Formula
C25H28ClN3O5
Molecular Weight
485.96
References & Citations
[1]Stephan A Veltkamp, et al. Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors. Clin Cancer Res. 2008 Nov 15;14 (22) :7535-44.|[2]S Okuno, et al. Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128) . Cancer Res. 2000 Jun 1;60 (11) :2988-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
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