T-2513
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].
Product Specifications
CAS Number
288247-87-0
UNSPSC
12352005
Target
DNA/RNA Synthesis; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t-2513.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC(OCCCN)=CC=C5N=C4C3=C2)=O
Molecular Formula
C25H27N3O5
Molecular Weight
449.50
References & Citations
[1]Stephan A Veltkamp, et al. Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors. Clin Cancer Res. 2008 Nov 15;14 (22) :7535-44.|[2]S Okuno, et al. Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128) . Cancer Res. 2000 Jun 1;60 (11) :2988-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9461002-02 5x 0.1 mL
CNR2 CB2 Polyclonal Antibody Cy3 Conjugated
Sign In for Pricing
View Details 