Bleomycin A5 (hydrochloride)

Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death[1][2][3][4]..

Product Specifications

CAS Number

[55658-47-4]

Product Name Alternative

Pingyangmycin (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H317-H319-H334-H335-H361

Target

Antibiotic; Apoptosis

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/bleomycin-a5-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCNCCCCN)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@H](O)[C@H](CO)O5)O)O[C@@]6([H])[C@H]([C@H]([C@H](O)[C@@H](CO)O6)OC(N)=O)O.[x]

Molecular Formula

C57H90ClN19O21S2

Molecular Weight

1477.02

Precautions

P261-P264-P270-P271-P272-P280-P284-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yang LC, et al. MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med. 2004;33 (1) :37-45.|[2]Wu F, et al. Bleomycin A5 suppresses Drp1 mediated mitochondrial fission and induces apoptosis in human nasal polyp derived fibroblasts. Int J Mol Med. 2021;47 (1) :346-360. |[3]Pan JB, et al. Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats. Respirology. 2009;14 (7) :975-982. |[4]He Y, et al. Pingyangmycin and Bleomycin Share the Same Cytotoxicity Pathway. Molecules. 2016;21 (7) :862. Published 2016 Jun 30.