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(S, R, S) -MI-1061

(S, R, S) -MI-1061 is the isomer of MI-1061 (HY-125858) . (S, R, S) -MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs) . MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM) . MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].

Product Specifications

CAS Number

[1410738-90-7]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; MDM-2/p53

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s-r-s-mi-1061.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@]2(C3=CC=C(Cl)C=C3N1)C4(CCCCC4)N[C@@H]([C@H]2C5=C(C(Cl)=CC=C5)F)C(NC6=CC=C(C=C6)C(O)=O)=O

Molecular Formula

C30H26Cl2FN3O4

Molecular Weight

582.45

References & Citations

[1]Nathan FISHKIN, et al. Linkers for use in antibody drug conjugates. WO2023037268A1.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Curated Selection

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