(S, R, S) -MI-1061
(S, R, S) -MI-1061 is the isomer of MI-1061 (HY-125858) . (S, R, S) -MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs) . MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM) . MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].
Product Specifications
CAS Number
[1410738-90-7]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; MDM-2/p53
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s-r-s-mi-1061.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@]2(C3=CC=C(Cl)C=C3N1)C4(CCCCC4)N[C@@H]([C@H]2C5=C(C(Cl)=CC=C5)F)C(NC6=CC=C(C=C6)C(O)=O)=O
Molecular Formula
C30H26Cl2FN3O4
Molecular Weight
582.45
References & Citations
[1]Nathan FISHKIN, et al. Linkers for use in antibody drug conjugates. WO2023037268A1.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
ZNF57, NT (ZNF57, ZNF424, Zinc finger protein 57, Zinc finger protein 424) (AP) discontinued
