(S, R, S) -MI-1061
(S, R, S) -MI-1061 is the isomer of MI-1061 (HY-125858) . (S, R, S) -MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs) . MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM) . MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].
Product Specifications
CAS Number
[1410738-90-7]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; MDM-2/p53
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s-r-s-mi-1061.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@]2(C3=CC=C(Cl)C=C3N1)C4(CCCCC4)N[C@@H]([C@H]2C5=C(C(Cl)=CC=C5)F)C(NC6=CC=C(C=C6)C(O)=O)=O
Molecular Formula
C30H26Cl2FN3O4
Molecular Weight
582.45
References & Citations
[1]Nathan FISHKIN, et al. Linkers for use in antibody drug conjugates. WO2023037268A1.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
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