CCR4 antagonist 2
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1].
Product Specifications
CAS Number
2206788-99-8
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ccr4-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
ClC(C=C(Cl)C=C1)=C1[C@@H](C)N2N=C(C#N)C3=C2N=C(C4=CC[C@H](N5[C@H](CO)CCC5)[C@H](C)C4)C=N3
Molecular Formula
C26H28Cl2N6O
Molecular Weight
511.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR4
Frequently Asked Questions
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