Cytidine-5'-triphosphate-13C, d1 (dilithium)

Cytidine-5'-triphosphate-13C, d1 (Cytidine triphosphate-13C, d1 dilithium; 5'-CTP-13C, d1) dilithium is deuterium and 13C-labeled Cytidine-5'-triphosphate (HY-125818) . Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP) . Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.

Product Specifications

Product Name Alternative

Cytidine triphosphate-13C, d1 (dilithium) ; 5'-CTP-13C, d1 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Metabolic Disease

Concentration

100 mM in 20.12 μL Tris HCl/D2O buffer pH=7.5

Purity

97.1

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N2[13CH]=C([2H])C(N)=NC2=O)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O)=O)(O)=O

Molecular Formula

C8 13CH13DLi2N3O14P3

Molecular Weight

497.02

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Heidy Y Narvaez-Ortiz, et al. A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii. Front Cell Infect Microbiol. 2018 Mar 22;8:83.