TNKS1/2-IN-1
TNKS1/2-IN-1 is a potent tankyrase TNKS1/2 inhibitor with pIC50s ranging from 7.1-8.2. TNKS1/2-IN-1 can be used for research of cancer, fibrosis, and other hyperproliferative diseases[1].
Product Specifications
CAS Number
[1498300-31-4]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tnks1-2-in-1.html
Purity
99.24
Solubility
10 mM in DMSO
Smiles
O=C(N1C[C@H]2CC[C@H](C(O)=O)CC2)N(CC3=CC=CC(C(F)(F)F)=C3C#N)C4=CC=C(F)C(C)=C4C1=O
Molecular Formula
C26H23F4N3O4
Molecular Weight
517.47
References & Citations
[1]Keenan Richard M, et al. Preparation of quinazolinediones as tankyrase inhibitors for the treatment of cancer: World Intellectual Property Organization, WO2013177349 A2 2013-11-28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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