Actinomycin X2

Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection[1][2].

Product Specifications

CAS Number

[18865-48-0]

Product Name Alternative

Actinomycin V

UNSPSC

12352209

Hazard Statement

H300, H310, H330, H361

Target

Antibiotic; Apoptosis; Bacterial

Type

Peptides

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/actinomycin-x2.html

Purity

98.00

Solubility

DMSO : 12.7 mg/mL (ultrasonic; warming)

Smiles

O=C(N[C@H](C(N[C@H](C(C)C)C(N([C@@]([H])(C1)C2=O)CC1=O)=O)=O)[C@@H](C)OC([C@H](C(C)C)N(C)C(CN2C)=O)=O)C(C3=NC4=C(C(N[C@H](C(N[C@H](C(C)C)C(N5[C@@]([H])(CCC5)C6=O)=O)=O)[C@@H](C)OC([C@H](C(C)C)N(C)C(CN6C)=O)=O)=O)C=CC(C)=C4OC3=C7C)=C(N)C7=O

Molecular Formula

C62H84N12O17

Molecular Weight

1269.40

Precautions

H300, H310, H330, H361

References & Citations

[1]Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach (Periplaneta americana) . Front Microbiol. 2020 Apr 7;11:555.|[2]Liu J, et al. Apoptosis of human prostate cancer cells induced by marine actinomycin X2 through the mTOR pathway compounded by MiRNA144. Anticancer Drugs. 2016 Mar;27 (3) :156-63.