Thiocillin I
Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively[1].
Product Specifications
CAS Number
59979-01-0
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thiocillin-i.html
Purity
96
Solubility
10 mM in DMSO
Smiles
C[C@H](C(N1)C2=NC(C3=NC(C4=NC(C5=NC(C(N/C(C(NC[C@H](O)C)=O)=C\C)=O)=CS5)=CS4)=CC=C3C6=NC(C(N[C@@](C(N/C(C7=NC(C(N[C@@H](C(C)(O)C)C8=NC(C1=O)=CS8)=O)=CS7)=C\C)=O)([H])[C@H](O)C)=O)=CS6)=CS2)O
Molecular Formula
C48H49N13O10S6
Molecular Weight
1160.37
References & Citations
[1] Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo (vi) catalyst. Chem Sci. 2018 Dec 3;10 (7) :1971-1975.|[2]Pandit B, et al. Proteasome inhibitory activity of thiazole antibiotics. Cancer Biol Ther. 2011 Jan 1;11 (1) :43-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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