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Thiocillin I

Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/thiocillin-i.html

Purity

96

Solubility

10 mM in DMSO

Smiles

C[C@H](C(N1)C2=NC(C3=NC(C4=NC(C5=NC(C(N/C(C(NC[C@H](O)C)=O)=C\C)=O)=CS5)=CS4)=CC=C3C6=NC(C(N[C@@](C(N/C(C7=NC(C(N[C@@H](C(C)(O)C)C8=NC(C1=O)=CS8)=O)=CS7)=C\C)=O)([H])[C@H](O)C)=O)=CS6)=CS2)O

Molecular Formula

C48H49N13O10S6

Molecular Weight

1160.37

References & Citations

[1] Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo (vi) catalyst. Chem Sci. 2018 Dec 3;10 (7) :1971-1975.|[2]Pandit B, et al. Proteasome inhibitory activity of thiazole antibiotics. Cancer Biol Ther. 2011 Jan 1;11 (1) :43-7.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-125733/Thiocillin-I-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-125733/

Scientific Category

Natural Products

Clinical Information

No Development Reported

CAS Number

[59979-01-0]

Available Sizes

Curated Selection

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