VU0029251
VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM) . VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC50: 1.7 μM) [1].
Product Specifications
CAS Number
330819-85-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0029251.html
Solubility
10 mM in DMSO
Smiles
NC1=C2C(SC3=C2CCC3)=NC(SC)=N1
Molecular Formula
C10H11N3S2
Molecular Weight
237.34
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Rodriguez, A.L., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol. Pharmacol. 78 (6), 1105-1123 (2010) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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