VU0029251

VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM) . VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC50: 1.7 μM) [1].

Product Specifications

CAS Number

[330819-85-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0029251.html

Solubility

10 mM in DMSO

Smiles

NC1=C2C(SC3=C2CCC3)=NC(SC)=N1

Molecular Formula

C10H11N3S2

Molecular Weight

237.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Rodriguez, A.L., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol. Pharmacol. 78 (6), 1105-1123 (2010) .