CK2-IN-9
CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC50 of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC50 of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat[1].
Product Specifications
CAS Number
1461658-58-1
UNSPSC
12352005
Target
Casein Kinase; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ck2-in-9.html
Solubility
10 mM in DMSO
Smiles
O=C(C)NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1N(CCN(C)C)C
Molecular Formula
C23H29N9O
Molecular Weight
447.54
References & Citations
[1]Dowling JE, et al. Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. ACS Med Chem Lett. 2016 Jan 20;7 (3) :300-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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