Cyclothialidine
Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor isolated from Streptomyces filipinensisNR0484[1].
Product Specifications
CAS Number
[147214-63-9]
Product Name Alternative
Ro 09-1437
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyclothialidine.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CSCC1=C(O)C=C(O)C(C)=C1C(OC2)=O)C(N[C@@H](C)C(O)=O)=O)[C@H]2NC([C@H]3N(CC[C@H]3O)C([C@@H](N)CO)=O)=O
Molecular Formula
C26H35N5O12S
Molecular Weight
641.65
References & Citations
[1]Angehrn P, et al. New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine. J Med Chem. 2004;47 (6) :1487-1513.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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