DBCO-NHCO-PEG4-acid
DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-NHCO-PEG4-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
CAS Number
[1870899-46-9]
UNSPSC
12352203
Hazard Statement
H315-H319-H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-nhco-peg4-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(CCOCCOCCOCCOCCOCCC(O)=O)=O
Molecular Formula
C32H40N2O9
Molecular Weight
596.67
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Vukic Soskic, et al. Method for binding biologically active molecules to surfaces. DE102014215208A1.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; PEG Linkers
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