Brevetoxin B
Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.
Product Specifications
CAS Number
[79580-28-2]
Product Name Alternative
Brevetoxin-2; PbTx-2
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Sodium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/brevetoxin-b.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C50H70O14
Molecular Weight
895.08
Precautions
H300+H310+H330
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12546/Brevetoxin-B-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12546/Brevetoxin-B-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
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