Brevetoxin-3

Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) [1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2].

Product Specifications

CAS Number

[85079-48-7]

Product Name Alternative

PbTx-3

UNSPSC

12352005

Hazard Statement

H300, H410

Target

Sodium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/brevetoxin-3.html

Purity

95.0

Solubility

Ethanol : 10 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12[C@](C[C@@]3([H])[C@@](C)(CC[C@@]4([H])[C@]([C@@H](C[C@@]5([H])[C@](C[C@@]6(C)[C@](C[C@@](O7)([H])[C@](C(C)=CC7=O)([H])O6)([H])O5)([H])O4)C)([H])O3)O2)([H])O[C@]8(C)[C@@](O[C@]9([H])[C@@](O[C@]%10([H])[C@@](O[C@]%11(C)[C@@](O[C@H](CC(CO)=C)C[C@@H]%11O)([H])C%10)([H])C9)([H])/C=C\C8)([H])C1

Molecular Formula

C50H72O14

Molecular Weight

897.10

Precautions

H300, H410

References & Citations

[1]Jeglitsch G, et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.J Pharmacol Exp Ther. 1998 Feb;284 (2) :516-25.|[2]Zaias J, et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.Inhal Toxicol. 2011 Mar;23 (4) :205-11.|[3]Benson JM, et al. Placental transport of brevetoxin-3 in CD-1 mice.Toxicon. 2006 Dec 15;48 (8) :1018-26. Epub 2006 Aug 18.