AM8191 (hydrochloride)

AM8191 is an orally active bactericidal and selectively inhibits DNA synthesis and Staphylococcus aureus gyrase (IC50=1.02 μM) and topo IV (IC50=10.4 μM) . AM8191 inhibits S. aureus MSSA (MIC=0.02 μg/mL) and S. aureus MRSA (MIC=0.06 μg/mL) [1].

Product Specifications

CAS Number

[1417548-17-4]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/am8191-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=NC(CNC34CCC(OC3)(CC4)[C@@H](O)CC5=C(F)C=NC6=CC=C(OC)N=C56)=CC=C2OC1.Cl

Molecular Formula

C26H29ClFN5O5

Molecular Weight

545.99

References & Citations

[1]Sheo B Singh, et al. Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. ACS Med Chem Lett. 2014 Mar 12;5 (5) :609-14.