AM8191 (hydrochloride)
Product Specifications
UNSPSC Description
AM8191 is an orally active bactericidal and selectively inhibits DNA synthesis and Staphylococcus aureus gyrase (IC50=1.02 μM) and topo IV (IC50=10.4 μM). AM8191 inhibits S. aureus MSSA (MIC=0.02 μg/mL) and S. aureus MRSA (MIC=0.06 μg/mL)[1].
Target Antigen
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/am8191-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=NC(CNC34CCC(OC3)(CC4)[C@@H](O)CC5=C(F)C=NC6=CC=C(OC)N=C56)=CC=C2OC1.Cl
Molecular Weight
545.99
References & Citations
[1]Sheo B Singh, et al. Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. ACS Med Chem Lett. 2014 Mar 12;5(5):609-14.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125424/AM8191-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125424/
Clinical Information
No Development Reported
CAS Number
1417548-17-4
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