PI3Kδ-IN-3
PI3Kδ-IN-3 (Compound 11) is a PI3Kδ inhibitor (IC50: 9 nM) . PI3Kδ-IN-3 inhibits B cell function. PI3Kδ-IN-3 has good pharmacokinetic properties[1].
Product Specifications
CAS Number
[1431540-99-6]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-3.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC(C2=CC3=C(C4=CC=CC(C(N5CCN(C(C)=O)CC5)=O)=C4)N=CN=C3C=C2)=CN=C1OC
Molecular Formula
C28H24N6O3
Molecular Weight
492.53
Precautions
H302, H312, H332
References & Citations
[1]Hoegenauer K, et al. Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2016 Jun 2;7 (8) :762-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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