JTP-117968

JTP-117968, a novel selective glucocorticoid receptor modulator (a non-steroidal SGRM, IC50 of 6.8 nM), exhibits improved transrepression/transactivation dissociation[1].

Product Specifications

CAS Number

2250132-99-9

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/jtp-117968.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C=C1C2)=CC=C1[C@]3(CC4=CC=CC=C4)CC[C@@](C(F)(F)F)(O)C[C@@]3([H])C52CC5)NC6=CC=CN=C6C

Molecular Formula

C31H31F3N2O2

Molecular Weight

520.59

References & Citations

[1]Takafumi Kurimoto, et al. JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation. Eur J Pharmacol. 2017 May 15;803:179-186.